Publications Using the Biomolecular NMR Facility Since 2000

A.I. Arunkumar, V. Klimovich, X. Jiang, R.D. Ott, L. Mizoue, E. Fanning* and W.J. Chazin*. "Structural and functional insights into RPA32 C-terminal domain-mediated assembly of the simian virus 40 replisome." Nature Structural and Molecular Biology 12, 332-339 (2005).

C.W. Vander Kooi, M.D. Ohi, J.A. Rosenberg, M.L. Oldham, M.E. Newcomer, K.L. Gould, and W.J. Chazin. "Structure of the Dimeric U-box of Prp19 Suggests A Common Structural Organization for Oligomeric E3 Ubiquitin Ligases." submitted.

J.H. Sheehan, C.G. Bunick, H. Hu, P.A. Fagan and W.J. Chazin. "Structure of the N-terminal Calcium Sensor Domain of Centrin Reveals the Biochemical Basis for Domain-Specific Function". submitted.

M.D. Ohi, C.W. Vander Kooi, J.A. Rosenberg, L. Ren, J.P. Hirsch, W.J. Chazin, T. Walz, and K.L. Gould. "Prp19p tetramerization is required for pre-mRNA splicing." Mol. Cell Biol. 25, 451-460 (2005).

S. Bhattacharya, Y.-T. Lee, W. Michowski, B. Jastrzebska, A. Filipek, J. Kuznicki and W.J. Chazin. "The modular structure of SIP facilitates its role in stabilizing multi-protein assemblies." Biochemistry 44, 9462-9471 (2005).

V.N. Shah, T.L. Wingo, K.L. Weiss, C.K. Williams, J.R. Balser and W.J. Chazin. "Calcium-dependent regulation of the cardiac voltage-gated sodium channel hH1: Intrinsic and extrinsic sensors act through a common molecular switch." submitted.

Whitson, SR, LeStourgeon, WM, Krezel, AM. Solution structure of the symmetric coiled coil tetramer formed by the oligomerization domain of hnRNP C: implications for biological function. J Mol Biol, 350(2), 319-37, (2005).

Changlin Tian, Murthy D. Karra, Charles D. Ellis, Jaison Jacob, Frank D. Sönnichsen, and Charles R. Sanders. "Membrane protein sample preparation for TROSY NMR Screening." Methods in Enzymology 394, 321-334. (2005)

Charles R. Sanders "Development and Application of Bicelles for Use in

Biological NMR and Other Biophysical Studies." Handbook of Modern Magnetic Resonance, G. Webb, Editor, Kluwer (in press). (2005)

Tian, C., Breyer, R. M., Kim, H. K., Karra, M.D., Friedman, D. B., and Sanders, C. R. "Solution NMR spectroscopy of the human vasopressin V2 receptor, a G protein-coupled receptor." J. American Chemical Society 127, 8010-8011. (2005)

Merritt, W.K., Kowalczyk, A., Scholdberg, T.A., Dean, S.M., Harris, T.M., Harris, C.M., Lloyd, R.S., and Stone, M.P. "Dual Roles of Stereochemical Configuration and Glycosyl Torsion Angle Conformation Upon trans-Lesion Replication of Butadiene Oxide-Derived N1 b-Hydroxyalkyl Deoxyinosine Adducts: A Structural Perspective." Chem. Res. Toxicol. 18, 1098-1107 (2005).

Merritt, W.K., Nechev, L.V., Scholdberg, T.A., Dean, S.M., Kiehna, S.E., Chang, J.C., Harris, T.M., Harris, C.M., Lloyd, R.S., and Stone, M.P. Structure of the 1,4-Bis(2'-deoxyadenosin-N6-yl)-2R,3R-Butanediol Crosslink Arising from Alkylation of the Human N-ras Codon 61 by Butadiene Diepoxide." Biochemistry 44, 3327-3337 (2005).

Moulaei, T., Maehigashi, T., Lountos, G., Komeda, S., Watkins, D., Stone, M.P., Marky, L., Li, J.-S., Gold, B., & Williams, L.D. "Structure of B-DNA with Cations Tethered in the Major Groove." Biochemistry 44, 7458-7468. (2005).

Scholdberg, T.A., Merritt, W.K., Dean, S.M., Kowalcyzk, A., Harris, C.M., Harris, T.M., Lloyd, R.S., & Stone, M.P. "Structure of an Oligodeoxynucleotide Containing a Butadiene Oxide-Derived N1 (-Hydroxyalkyl Deoxyinosine Adduct in the Human N-ras Codon 61 Sequence." Biochemistry 44, 3327-3337. (2005).

Scholdberg, T.A., Nechev, L.V., Merritt, W.K., Harris, T.M., Harris, C.M., Lloyd, R.S., & Stone, M.P. "Mispairing of a Site-Specific Major Groove (2S,3S)-N6-(2,3,4-Trihydroxybutyl)-2'-deoxyadenosyl DNA Adduct of Butadiene Diol Epoxide with Deoxyguanosine: Formation of a dA(anti)•dG(anti) Pairing Interaction." Chem. Res. Toxicol. 18, 145-153. (2005)

Schneider, C., Boeglin, W.E., Yin, H., Stec, D.F., and Voehler, M. "Convergent oxygenation of arachidonic acid by 5-lipoxygenase and cyclooxygenase-2," J. Am. Chem. Soc., submitted. (2005)

Zhao B, Guengerich FP, Bellamine A, Lamb DC, Izumikawa M, Lei L, Podust LM, Sundaramoorthy M, Kalaitzis JA, Reddy LM, Kelly SL, Moore BS, Stec D, Voehler M, Falck JR, Shimada T, Waterman MR. "Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2."J Biol Chem.;280(12):11599-607. (2005)

Zhao, B., Guengerich, F.P., Voehler, M., and Waterman, M.R. "Role of Active Site Water Molecules and Hydroxyl Groups of Substrate in Oxygen Activation by Cytochrome P450 158A2." J. Biol. Chem. (accepted) (2005)

C.G. Bunick, M.R. Nelson, S. Mangahas, M.J. Hunter, J.H. Sheehan, L.S. Mizoue, G.J. Bunick and W.J. Chazin. "Designing sequence to control function in an EF-hand Protein." J. Amer. Chem. Soc. 126, 5990-5998 (2004).

H. Highfield-Nickols, V.N. Shah, W.J. Chazin, and L.E. Limbird. "Calmodulin interacts with the V2 vasopressin receptor: Elimination of binding to the C-terminus also eliminates AVP-stimulated elevation of intracellular calcium." J. Biol. Chem. 279, 46969-46980 (2004).

H. Hu, J.H. Sheehan and W.J. Chazin. "The Mode of Action of Centrin: Binding of Ca2+ and a Peptide Fragment of Kar1p to the C-terminal Domain." J. Biol. Chem. 279, 50895-50903 (2004).

J. Christodoulou, J.F. Harper, A. Malmendal and W.J. Chazin. "Insights into the Regulation of Calcium-Dependent Protein Kinase (CDPK) by Calcium and the Autoinhibitory Junction." J. Biol. Chem. 279, 29092-29100 (2004).

M.E. Stauffer and W.J. Chazin. "Physical Interaction between RPA and Rad51 is Essential for Efficient Initiation of Recombination." J. Biol. Chem. 279, 25638-25645 (2004).

S. Bhattacharya, A.I. Arunkumar and W.J. Chazin." 1H, 15N and 13C assignments of the tandem high affinity ssDNA binding domains of replication protein A." J. Biomol. NMR 28, 195-196. (2004).

S. Bhattacharya, A.I. Arunkumar, S.L. Sullivan, M.-V. Botuyan, C.H. Arrowsmith and W.J. Chazin. "Letter to the Editor: 1H, 13C and 15N assignments of single-stranded DNA binding domains from the 70 kDa subunit of Human Replication Protein A." J. Biomol. NMR. 28, 195-196 (2004).

T.L. Wingo, V.N. Shah, M.E. Anderson, T.P. Lybrand, W.J. Chazin* and J.R. Balser*. "An EF-Hand in the sodium channel couples intracellular calcium to cardiac excitability." Nature Structural & Molecular Biology 11, 219-225 (2004).

Y.-T. Lee, J. Jacob, W. Michowski, M. Nowotny, J. Kuznicki and W.J. Chazin. "Human Sgt1 binds to HSP90 through its CS domain: CS domain is a general binding module for HSP90." J. Biol. Chem. 279, 16511-16517 (2004).

Chim, Nicholas, Gall, Walter E, Xiao, Jing, Harris, Mark P, Graham, Todd R, Krezel, Andrzej M. Solution structure of the ubiquitin-binding domain in Swa2p from Saccharomyces cerevisiae. Proteins, 54(4), 784-93, (2004).

C.R. Sanders and J.K. Meyers." Disease-Related Misassembly of Membrane Proteins." Annual Review of Biophysics and Biomolecular Structure 33, 25-51 (2004).

C.R. Sanders, A.K. Hoffman, D.N. Gray, M.H. Keyes, and C.D. Ellis." French swimwear for membrane proteins." ChemBioChem, in press. (2004).

J. K. Myers, and C.R. Sanders." Phenotology of Disease-Linked Proteins." Submitted to Proceedings of the National Academy of Sciences. (2004)

J.K. Nagy, and C.R. Sanders." Destabilizing Mutations Promote Membrane Protein Misfolding." (Accelerated Publication) Biochemistry 43, 19-25 (2004)

Oxenoid, K., Kim, H.-K., Jacob, J., Sonnichsen, F. D., and Sanders, C. R. NMR "Assignments for a Helical 40 kDa Membrane Protein in 100 kDa Micelles." J. American Chemical Society 126, 5048-5049. (2004)

Hashim, M.F., Riggins, J.N., Schnetz-Boutaud, N., Voehler, M., Stone. M.P., & Marnett, L.J. "In Vitro Bypass of Malondialdehyde-Deoxyguanosine Adducts: Base Selection During Extension by the Klenow Fragment of DNA Polymerase I is the Critical Determinant of Replication Outcome." (2004) Biochemistry 43, 11828-11835.

Merritt, W.K., Nechev, L.N., Scholdberg, T.A., Harris, C.M., Harris, T.M., Lloyd, R.S., & Stone, M.P. "Stereospecific Structural Perturbations Arising from Adenine N6 Butadiene Triol Adducts in Duplex DNA." (2004) Chem. Res. Toxicol. 17, 1007-1019.

Scholdberg, T.A., Nechev, L.N., Merritt, W.K., Harris, T.M., Harris, C.M., Lloyd, R.S., & Stone, M.P. "Structure of the Site-Specific Major Groove (2S,3S)-N6-(2,3,4-trihydroxybutyl)-2'-deoxyadenosyl Adenine N6 Adduct of Butadiene Diol Epoxide." (2004) Chem. Res. Toxicol. 17, 717-730.

Krauser, J.A., Voehler, M., Tseng, L-H., Schefer, A.B., Godejohann, M., and Guengerich, F.P. "Testosterone 1b-Hydroxylation by Human Cytochrome P450 3A4." Eur. J. Biochem. 271, 3962-3969. (2004)

A. Malmendal, S. Halpain and W.J. Chazin." Biophysical Characterization of Protected Domains in Microtubule-Associated Protein 2." Biochem. Biophys. Res. Commun. 301, 136-142 (2003).

A.I. Arunkumar, M.E. Stauffer, E. Bochkareva, A. Bochkarev, and W.J. Chazin ." Independent and coordinated functions of the Replication Protein A tandem high affinity ssDNA binding domains." J. Biol. Chem. 278, 41077-41082 (2003).

H. Hu and W.J. Chazin." Unique Features in the C-terminal Domain Provide Caltractin with Target Specificity." J. Mol. Biol. 330, 473-484 (2003).

J.-H. Lee, C.-J. Park, A.I. Arunkumar, W.J. Chazin and B.-S. Choi" NMR study on the interaction between RPA and DNA decamer-containing cis-syn cyclobutane pyrimidine dimer in the presence of XPA: Implication for damage verification and strand-specific dual incision in nucleotide excision repair". Nucleic Acids Research 31, 4747-4754 (2003).

M.D. Ohi, C.W. Vander Kooi, J.A. Rosenberg, W.J. Chazin and K. L. Gould." Structural Insights Into the U-box, A Domain Associated with Multi-Ubiquitination." Nature Structural Biol. 11, 250-255 (2003).

S. Bhattacharya and W.J. Chazin." Calcium Driven Changes in S100A11 Structure Revealed." Structure 11, 738-740 (2003).

S. Bhattacharya, E. Large, C.W. Heizmann, B. Hemmings and W.J. Chazin." Structural mechanism of calcium dependent regulation of the NDR Kinase by S100B." Biochemistry 42, 14416-14426 (2003).

M.S. Marlow, C.B. Brown, J.V. Barnett, and A.M. Krezel." Solution structure of the chick TGFbeta type II receptor ligand-binding domain." J. Mol. Biol. 326, 989-97, (2003)

H.-Y. Kim, A.S. Wilkinson, C.M. Harris, T.M. Harris, and M.P. Stone." Minor Groove Orientation for the(1S,2R,3S,4R)-N2-[1-(1,2,3,4-tetrahydro-2,3,4-trihydroxy-benz[a]anthracenyl)]-2'-deoxyguanosyl Adduct in the N-ras Codon 12 Sequence." Biochemistry 42, 2328-2338. (2003)

I. Giri, and M.P. Stone." Wobble dC-dA Pairing 5' to the Cationic Guanine N7 8,9-Dihydro-8-(N7-guanyl)-9-Hydroxy-Aflatoxin B1 Adduct: Implications for Non-targeted AFB1 Mutagenesis." Biochemistry 42, 7023-7034 (2003).

I.D. Kozekov, L.V. Nechev, M.S. Moseley, C.M. Harris, C.J. Rizzo, M.P. Stone, and T.M. Harris." DNA Interchain Crosslinks Formed by Acrolein and Crotonaldehyde." J. Am. Chem. Soc. 125, 50-61. (2003)

P.A. Dooley, M. Zhang, G.A. Korbel, L.V. Nechev, C.M. Harris, M.P. Stone, and T.M. Harris." NMR Determination of the Conformation of a Trimethylene Interstrand Crosslink in an Oligodeoxynucleotide Duplex Containing a 5'-d(GpC) Motif." J. Am. Chem. Soc. 125, 62-72. (2003)

Christodoulou, H. Hu, J. Chung, M. Rance, J.F. Harper and W.J. Chazin." 1H, 15N and 13C assignments of the regulatory domains of calcium-dependent protein kinase (CDPK)." J. Biomolec. NMR 23, 249-250 (2002).

S. Bhattacharya, M.V. Botuyan, F. Hsu, X. Shan, A.I. Arun Kumar, C.H. Arrowsmith, A.M. Edwards and W.J. Chazin." Characterization of Backbone Dynamics Suggests a Model for Sequence Non-Specific Binding of ssDNA by Replication Protein A." Protein Science 11, 2316-2325 (2002).

S. Veeraraghavan, P.A. Fagan, H. Hu, V. Lee, J.F. Harper, B. Huang and W.J. Chazin." Structural independence of the two EF-hand domains of caltractin." J. Biol. Chem. 277, 28564-28571 (2002).

H.-Y. Kim, M. Voehler, T.M. Harris, and M.P. Stone." Detection of an Interchain Carbinolamine Crosslink Formed in a CpG Sequence by the Acrolein DNA Adduct ?-OH-1,N2-Propano-2'-deoxyguanosine J. Am. Chem. Soc. 124, 9324-9325 (2002).

I. Giri and M.P. Stone." Thermal Stabilization of the DNA Duplex by Adducts of Aflatoxin B1" Biopolymers 65, 190-201 (2002).

I. Giri, D.S. Johnston, and M.P. Stone." Mispairing of the 8,9-Dihydro-8-(N7-guanyl)-9-Hydroxy-Aflatoxin B1 Adduct with Deoxyadenosine Results in Extrusion of the Mismatched dA Toward the Major Groove." Biochemistry 41, 5462-5472 (2002).

I. Giri, M.D. Jenkins, H. Mao, W.R. Jones, N.C. Schnetz-Boutaud and M.P. Stone." Structural Refinement of the 8,9-Dihydro-8-(N7-guanyl)-9-hydroxy-aflatoxin B1 Adduct in a 5'-CpAFBG-3' Sequence" (2002) Chem. Res. Toxicol. 15, 638-647 (2002).

J.P. Weisenseel, L.J. Marnett, and M.P. Stone." Structure of an Oligodeoxynucleotide Containing a 1,N2-Propanodeoxyguanosine Adduct Positioned in a Palindrome Derived from the Salmonella typhimurium hisD3052 Gene: Hoogsteen Pairing at pH 5.2." Chem. Res. Toxicol. 15, 140-152 (2002).

J.P. Weisenseel, L.J. Marnett, and M.P. Stone." Structure of the 1,N2-Propanodeoxyguanosine Adduct In a 3-base DNA Hairpin Loop Derived From a Palindrome in the Salmonella typhimurium hisD3052 Gene." Chem. Res. Toxicol. 15, 127-139 (2002).

Z. Li, L. Huang, P. Dande, B. Gold and M.P. Stone." Structure of a Tethered Cationic 3-Aminopropyl Chain Incorporated into an Oligodeoxynucleotide: Evidence for 3'-Orientation in the Major Groove Accompanied by DNA Bending" J. Am. Chem. Soc. 124, 8553-8560 (2002).

A. Randazzo, C. Acklin, B.W. Shaefer, C.W. Heizmann and W.J. Chazin." Structural insight into Zn2+-bound S100A2 from NMR and homology modeling." Biochem. Biophys. Res. Commun., 462-467 (2001).

L. Shahied, E.H. Braswell, W.M. LeStourgeon, A.M. Krezel" An antiparallel four-helix bundle orients the high-affinity RNA binding sites in hnRNP C: a mechanism for RNA chaperonin activity." J. Mol. Biol. 305, 817-828 (2001).

C. Hennard., J. Finneman, C.M. Harris, T.M. Harris, and M.P. Stone." The Non-mutagenic R- and S-?-(N6-Adenyl)-Styrene Oxide Adducts are Oriented in the Major Groove and Show Little Perturbation to DNA Structure." Biochemistry 40, 9780-9791 (2001).

N.C. Schnetz-Boutaud, S. Saleh, L.J. Marnett, and M.P. Stone." The Exocyclic 1,N2-Deoxyguanosine Pyrimidopurinone M1G is a Chemically Stable DNA Adduct When Placed Opposite a Two Base Deletion in the (CpG)3 Frameshift Hotspot of the Salmonella typhimurium hisD3052 Gene." Biochemistry 40, 15638-15649 (2001).

P.A. Dooley, D. Tsarouhtsis, G.A. Korbel, L.V. Nechev, J. Shearer, I.S. Zegar, C.M. Harris, M.P. Stone, and T.M. Harris." Structural Studies of an Oligodeoxynucleotide Containing a Trimethylene Interstrand Cross-Link in a 5'-(CpG) Motif: Model of a Malondialdehyde Cross-Link." J. Am. Chem. Soc. 123, 1730-1739 (2001).

Z. Li, P.J. Tamura, A.S. Wilkinson, C.M. Harris, T.M. Harris, and M.P. Stone." Intercalation of the (1R,2S,3R,4S)-N6-[1-(1,2,3,4-Tetrahydro-2,3,4-trihydroxy-benz[a]anthracenyl)]-2'-deoxyadenosyl Adduct in the N-ras Codon 61 Sequence: DNA Sequence Effects." Biochemistry 40, 6743-6755 (2001).

M. Nowotny, S. Bhattacharya, A. Filipek, W.J. Chazin, and J. Kuznicki." Characterization of the interaction of calcyclin (S100A6) and calcyclin-binding protein." J. Biol. Chem. 275, 31178-31182 (2000).

A.M. Krezel, J.S. Ulmer, G. Wagner, R.A. Lazarus." Recombinant decoursin:dynamics of the RGD recognition site." Protein Sci. 9, 1428-1438 (2000).

M.S. Marlow, N. Chim, C.B. Brown, J.V. Barnett, A.M. Krezel." 1H, 13C, and 15N backbone assignments of the ligand binding domain of TGFbeta type II receptor." J. Biomol. NMR. 17, 349-350 (2000).

J.S. Johnston, & M.P. Stone," Replication of a Site-Specific trans-8,9-Dihydro-8-(N7-guanyl)-9-hydroxyaflatoxin B1 Adduct by the Exonuclease Deficient Klenow Fragment of DNA Polymerase I" Chem. Res. Toxicol. 13, 1158-1164 (2000).

M.F. Simeonov, P.J. Tamura, A.S. Wilkinson, C.M. Harris, T.M. Harris, and M.P. Stone." Sequence- and Stereospecific Conformational Rearrangement of Styrene Oxide Adducts Located at A-C Mismatched Base Pairs." Biochemistry 39, 924-937 (2000).

N.C. Schnetz-Boutaud, H. Mao, M.P. Stone and L.J. Marnett." Synthesis of Oligonucleotides Containing the Alkali-Labile Pyrimdopurinone Adduct-M1G." Chem. Res. Toxicol. 13, 90-95 (2000).

P.T.Q. Le, C.M. Harris, T.M. Harris, and M.P. Stone." Altered Electrophoretic Migration of Polycyclic Aromatic Hydrocarbon and Styrene Oxide Adducts at Adenine N6 Correlates with Adduct-Induced Structural Disorder." Chem. Res. Toxicol. 13, 63-71 (2000).

M.Voehler- modified on January 30, 2009